D-Ribose is a natural substance found in certain plants including sugar cane. It is an ose (sugar) whose chemical form is C5H10O5. This carbohydrate, present in every living organism, promotes the production of ATP (adenosine triphosphate).
It plays a special role in the regulation of energy synthesis. Therefore, D-Ribose, as a supplement to the daily diet, can help people with fibromyalgia and chronic fatigue syndrome to improve their muscle energy.
Since the ATP produced by D-Ribose will go directly to all muscles, people whose heart muscle has been damaged will also benefit from this nutritional supplement. Finally, for athletes engaged in intense physical activity, D-Ribose can help them quickly replenish energy reserves depleted by exercise.
Fibromyalgia and D-Ribose
Fibromyalgia is defined as a chronic and diffuse pain in the muscles. The pain appears in different parts of the body, without any apparent logic. Statistically, fibromyalgia seems to affect women more than men. In fact, fibromyalgia is one of those diseases that remain unexplained and whose limits remain unclear. Indeed, fibromyalgia shares its symptoms with other diseases such as rheumatism or osteoporosis. Nevertheless, what characterizes fibromyalgia is the combination of muscle pain with physical and psychological fatigue.
Physical fatigue is often caused by low ATP (adenosine trisphosphate) levels. ATP is the fuel of the cell, providing the energy for chemical reactions in the cell. A clinical study that took place in 2005 at the University of Salt Lake City (Utah) demonstrated the effectiveness of Ribose absorption in cases of fibromyalgia. A 37 year old woman suffering from muscle pain and tension, mental "fog", diarrhea and insomnia was diagnosed with fibromyalgia. Taking CorvalenTM, a Ribose-based product, at a rate of 5g twice a day, resulted in improved sleep, better mental activity, reduced physical pain and normalized bowel movements after 14 days (Gebhart and Jorgenson, 2005).
D-Ribose and chronic fatigue syndrome
Like fibromyalgia, chronic fatigue syndrome is an illness with unknown causes. D-Ribose, as a supplement to a healthy, varied and, if possible, organic diet, can be of considerable help to people with chronic fatigue syndrome.
A clinical study of 41 patients suffering from chronic fatigue syndrome and/or fibromyalgia - published by Jacob Teitelbaum, MD and Valen Labs in 2006 in the Journal of Alternative and Complementary Medicine - showed that taking 5 g of Ribose three times a day for a total of 280 g significantly improved the patients' chronic fatigue symptoms. D-Ribose was perfectly tolerated, and the following 5 areas in particular were significantly improved: energy, sleep, intellectual clarity, pain intensity and well-being.
D-Ribose, fitness and weight training
As athletes know, strenuous exercise can lead to disruptions in cellular energy. Sports, fitness and weight training often result in muscle stiffness, pain, toxin build-up and chronic fatigue. D-Ribose restores the levels of ATP which constitutes cellular energy, so its ingestion effectively increases the amount of energy usable for muscular exercise.
A study by Van Gammeren and Darin Falk published in 2002 on the effect of D-Ribose on healthy men aged between 18 and 35 years practicing body building in a gym. This study showed that D-Ribose at a dose of 10 g per day significantly increases resistance to intense physical effort.
Another study shows that taking D-Ribose reduces the heart rate of athletes who train at a constant intensity. In addition, D-Ribose helps to limit the production of free radicals linked to intense physical activity.
Cardiology and D-Ribose
People who have suffered a heart attack in their lives experience a loss of energy due to the lack of oxygen supply to the myocardial cells. As a result, heart function is impaired, which can lead to fatigue during exercise. D-Ribose supplementation can help to restore normal ATP levels in the heart and bring more comfort and vitality to everyday life.
In an article published in 2004 by Heyder Omran, MD et al, it was shown that Ribose could restore ATP to normal in impaired patients and thereby normalize diastolic function. This article cites a clinical study conducted by Pliml et al in 1992 involving 20 people with coronary artery disease: one group received 60 g of Ribose per day for three days, another group received a placebo. Both groups performed physical exercise before and after treatment. The group that received D-Ribose showed a greater resistance to exercise than the placebo group.
Therefore, the intake of D-Ribose may be useful after a myocardial infarction to strengthen the heart muscle if it has been affected. Comparative studies between healthy athletes and subjects who have suffered heart muscle damage show that supplying Ribose to fatigued muscle cells quickly restores normal ATP levels.
D-Ribose and ATP
Adenosine Triphosphate (ATP) is a very important molecule in all living things as it provides the energy for chemical reactions in the cell. ATP is the energy reserve of the cell and the living being can carry out an activity as long as its ATP levels allow it.
D-Ribose, a sugar (ose) with 5 carbon elements, is not only an essential constituent of RNA and DNA, but is also crucial for the manufacture of ATP. Mitochondria located in energy-intensive organs (heart, liver, brain, endocrine glands and muscles) use two methods to make or store ATP. The first is de novo synthesis: nucleotides are made from scratch and Ribose is an essential building block. The second is more rapid: the mitochondrion recovers pieces of ATP metabolites to form new ATP molecules. In this pathway, Ribose allows the cell to quickly and efficiently recycle the products of ATP metabolism to form new ATP molecules.
Several scientific studies have shown that oral intake of D-Ribose can rapidly restore normal ATP levels in muscles during ischemia.
Research and D-Ribose
1. Pliml, Wolfgang, Von Arnim, Thomas, Stablein, Alexander, et al. Effects of ribose on exercise-induced ischemia in stable coronary artery disease. The Lancet, 1992, 340, 507-510.
2. Illien, Steffan, Omran, H., MacCarter, D., and St. Cyr, J. Ribose improves myocardial function in congestive heart failure, FASEB Journal, 2001, 15: 5, A1142.
3. Van Gammeren, D., Falk, D., and Antonio, J. The effects of four weeks of ribose supplementation on body composition and exercise performance in healthy, young, male recreational body builders: A double-blind, placebo controlled trial. Current Therapeutic Research, 2002, 63: 8, 486-495.
4. Seifer, J.G., Subudhi, A., Fu, M.X., et al. The effects of ribrose ingestion on indices of free radical production during hypoxic exercise, Free Radical Biology and Medicine, 2002, 33 (Suppl 1): S269.
5.Jacob E. Teitelbaum, Clarence Johnson, John St. Cyr. The Use of D-Ribose in Chronic Fatigue Syndrome and Fibromyalgia: A Pilot Study, The Journal of Alternative and Complementary Medicine. November 2006, 12(9): 857-862. doi:10.1089/acm.2006.12.857
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